Hot News: DIAN Participant Defies Presenilin 2 Mutation
The man has lots of plaques but few tangles 18 years after his expected age of onset; potential protective factors include extensive heat shock protein expression.
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SPOTLIGHT
Hot News: DIAN Participant Defies Presenilin 2 Mutation
Boasting resilience to amyloid, Doug Whitney, a DIAN participant with the Volga PS2 mutation, has many plaques but few tangles, and he remains cognitively healthy 18 years past the age when Alzheimer's symptoms were estimated to start. Multiomic analyses suggest protective variants in CD33, tau, and other genes, but also an intriguing abundance of heat shock proteins and of metabolic factors implicated in aging research.
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