Lactylation—a New Protein Modification That Slows Alzheimer’s?
In mice, lactylation of APP reduces amyloid deposits and slows disease progression.
NEWS
Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Recent genetic and mechanistic studies on SORL1 place the endolysosomal system, in both neurons and microglia, front and center in the pathogenesis of AD.
Inhaled Xenon for AD?
In models of amyloidosis and tauopathy, the noble gas curbed inflammation and made microglia more phagocytic, resulting in fewer aggregates and healthier neurons.
New Atlas Catalogues Regulatory RNA Changes in Alzheimer’s
Survey of post-translationally modified and noncoding RNA identified more than 25,000 differences between AD and control brain.
Does the Brain Make Phospho-Tau to Fight Viruses?
In AD brain, cells ramp up expression of herpes virus proteins. In cultured neurons, these proteins boost p-tau, which then suppresses viral proteins.
Microglia Drive Neurodegeneration in Niemann-Pick Type C
In mice, eliminating the NPC1 gene from microglia recapitulated aspects of the lysosomal storage disorder.
Bile Acid: An Elixir of Youth?
In lab animals, lithocholic acid replicates life-extending benefits of caloric restriction.
One Last Round in an Open Debate: Final Exchange
Dennis Selkoe offers a closing response.
SPOTLIGHT
Inhaled Xenon for AD?
Could treating Alzheimer’s disease be as simple as inhaling xenon? Data from mice support this provocative idea. Huffing xenon for 40 minutes weekly shifted microglia from pro-inflammatory to phagocytic, allowing these immune cells to better corral plaques and prevent neurite degeneration. A Phase 1 trial in healthy elderly volunteers has started.
Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Mutations that slow SORL1 trafficking through the cell associate with AD, and recent work helps unveil the mechanisms involved. In neurons, SORL1 deficiency hobbles endosomal network, compromising recycling of proteins such as APP and synaptic receptors. In microglia, lysosomes suffer the consequences, accumulating undigested contents as crucial proteases get trapped in the trans-Golgi network. Check out Alzforum’s update to learn more about the latest science on this massive sorting receptor.
Join The Conversation
Professional Resources
New in last 7 days
-
Grants
- New Items: 7
- Total Items: 292
-
Jobs
- New Items: 2
- Total Items: 37
-
Conference Calendar
- New Items: 4
- Total Items: 116
- Member Directory
Latest Comments